Mismatch Repair Genes Matched to Several New Roles in Cancer

DNA mismatch repair genes and colorectal cancer.

Polymorphism of DNA mismatch repair genes in endometrial cancer.

UNLABELLED Endometrial cancer (EC) is the second most common malignancy associated with hereditary non-polyposis colorectal cancer (HNPCC) family. The development of HNPCC is associated with defects in DNA mismatch repair (MMR) pathway resulting in microsatellite instability (MSI). MSI is present in a greater number of EC than can be accounted for by inherited MMR mutations, therefore alternati...

DNA Mismatch Repair (MMR) Genes and Endometrial Cancer

Epimutation in DNA Mismatch Repair (MMR) Genes

Mismatch repair defects in cancer.

Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and 'atypical' hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between ...